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A combination of the medications methylcobalamin and pregabalin is known as methylcobalamin + pregabalin. A kind of vitamin B called methylcobalamin aids in the synthesis of myelin, which shields nerve fibers and repairs injured nerve cells. Pregabalin is an alpha-2 delta ligand that reduces pain by altering the activation of calcium channels in nerve cells. They work together to alleviate neuropathic pain, or pain resulting from injured nerves.