ADYSIL 400 contains Ademetionine, a naturally occurring compound found in the body that is essential for numerous metabolic pathways. It plays a crucial role in liver function, mood regulation, and joint health. As a dietary supplement and medication, Ademetionine is used to restore depleted levels in the body, offering hepatoprotective, anti-depressant, and anti-inflammatory benefits. ADYSIL 400 provides a high-quality, stable formulation to support cellular health and overall well-being. Indications ADYSIL 400 is indicated for the management of the following conditions: Intrahepatic Cholestasis: A liver condition associated with reduced bile flow, often occurring in chronic liver diseases or during pregnancy. Liver Disease: Including alcoholic liver disease, non-alcoholic fatty liver disease (NAFLD), and cirrhosis, to support liver function and protect liver cells from damage. Depression: As an adjunct therapy to help regulate mood by influencing neurotransmitter synthesis. Osteoarthritis: To help reduce joint pain, manage inflammation, and support cartilage health. Mechanism of Action Ademetionine functions through three primary metabolic pathways: methylation, trans-sulfuration, and aminopropylation. In the liver, it acts as a precursor to the antioxidant glutathione, a vital molecule for detoxification and protecting hepatocytes from toxins and oxidative stress. By increasing glutathione levels, it enhances the liver's ability to perform its normal functions. In the central nervous system, Ademetionine donates methyl groups required for the synthesis of key neurotransmitters like serotonin and dopamine, thereby helping to regulate mood. For joint health, it contributes to the production of proteoglycans, essential components for cartilage repair and maintenance, while also exhibiting anti-inflammatory properties. Side Effects ADYSIL 400 is generally well-tolerated. However, some individuals may experience side effects, including: Nausea Diarrhea or constipation Abdominal discomfort or pain Headache or dizziness Anxiety or insomnia in sensitive individuals Most side effects are mild and transient. If they persist or worsen, it is advisable to consult a healthcare professional. Contra-indications ADYSIL 400 should be used with caution or is contra-indicated in patients with: Known hypersensitivity to Ademetionine. Bipolar disorder, as it may trigger manic episodes. Genetic defects affecting the methionine cycle (e.g., homocystinuria). Patients who are pregnant, breastfeeding, or have severe renal impairment should consult their doctor before using this product. Conclusion ADYSIL 400 (Ademetionine 400mg) is a versatile therapeutic agent that provides essential support for liver health, mood balance, and joint function. Its multi-faceted mechanism of action makes it a valuable choice for managing a range of conditions, helping to restore physiological balance and improve quality of life.